2-(2-丙炔-1-基)丙二酸二乙酯合成路线 （共 24 条）
反应条件
1: 67 g / NaCl / dimethylsulfoxide; H2O / 40 h / Heating
2: 35.5 g / aq. KOH / methanol / 4 h / Heating
3: 1.) EtMgBr, 2.) CuCN, HMPT / 1.) THF, RT, 2 h, 2.) THF, 3 h
4: 79 percent / conc. H2SO4 / CCl4 / 10 h
5: LiAlH4 / bis-(2-methoxy-ethyl) ether; tetrahydrofuran / 20 h / 145 - 150 °C
6: 88 percent / pyridine / 24 h / Ambient temperature
View Scheme
参考文献
Gocan, Alexandra; Gansca, Lucia; Oprean, Ioan
Revue Roumaine de Chimie, 1995 , vol. 40, # 3 p. 253 - 258
反应条件
1: 67 g / NaCl / dimethylsulfoxide; H2O / 40 h / Heating
2: 35.5 g / aq. KOH / methanol / 4 h / Heating
3: 1.) EtMgBr, 2.) CuCN, HMPT / 1.) THF, RT, 2 h, 2.) THF, 3 h
4: 79 percent / conc. H2SO4 / CCl4 / 10 h
5: LiAlH4 / bis-(2-methoxy-ethyl) ether; tetrahydrofuran / 20 h / 145 - 150 °C
View Scheme
参考文献
Gocan, Alexandra; Gansca, Lucia; Oprean, Ioan
Revue Roumaine de Chimie, 1995 , vol. 40, # 3 p. 253 - 258
参考文献
d'Alcontres,G.S. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1976 , p. 1694 - 1696
反应条件
lithium chloride in dimethyl sulfoxide
Heating; Yield given;
参考文献
Tokuda, Masao; Fujita, Hirotake; Nitta, Makoto; Suginome, Hiroshi
Heterocycles, 1996 , vol. 42, # 1 p. 385 - 395
