3beta-O-乙酰基-雄甾-5,15-二烯-17-酮合成路线 （共 4 条）
反应条件
1: With boron trifluoride diethyl etherate in dichloromethane T=20°C; 2 h; 2: With water in dichloromethane
参考文献
BIOMARIN PHARMACEUTICAL INC.; CHU, Daniel; WANG, Bing; YE, Tao
Patent: WO2012/83112 A2, 2012 ;
Location in patent: Page/Page column 209 ;
WO 2012/083112 A2
反应条件
1: 17,17-ethylenedioxy-3β-hydroxyandrosta-5,15-diene With toluene-4-sulfonic acid in water; acetone 18 h; Inert atmosphere; 2: acetic anhydride With pyridine; 4-(N,N-dimethlyamino)pyridine in dichloromethane 24 h; Inert atmosphere;
参考文献
Russian Journal of General Chemistry, , vol. 81, # 9 p. 1877 - 1885
反应条件
1: 86 percent / diethyl ether / 14 h / 20 °C / 750.06 Torr 2: 23 percent / BF3*Et2O / acetone / 1 h / 20 °C 3: alkali / aq. ethanol View Scheme
参考文献
Kamernitskii, A. V.; Galakhova, T. N.; Levina, I. S.; El'yanov, V. S.; Bodganov, V. S.; Cherepanova, E. G.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1985 , vol. 34, p. 1743 - 1748
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1985 , # 8 p. 1893 - 1898
反应条件
sodium hydride 1.) DMSO, 20 deg C, 2.) 2 h;
参考文献
Kamernitskii, A. V.; Galakhova, T. N.; Levina, I. S.; El'yanov, V. S.; Bodganov, V. S.; Cherepanova, E. G.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1985 , vol. 34, p. 1743 - 1748
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1985 , # 8 p. 1893 - 1898
