1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere 1.2: -78 - 20 °C / Inert atmosphere 2.1: diisobutylaluminium hydride / hexane / 1.5 h / 0 °C / Inert atmosphere 3.1: toluene-4-sulfonic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 - 20 °C / Inert atmosphere 5.1: 4-methylmorpholine N-oxide / dichloromethane / 1 h / 20 °C / Molecular sieve 5.2: 0.67 h / 5 °C 6.1: bis(benzonitrile)palladium(II) dichloride; p-benozquinone / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere 7.1: ozone / methanol / 0.5 h / -78 °C 7.2: 0 - 20 °C 8.1: sodium hydride / tetrahydrofuran / 5 - 20 °C 8.2: 5 - 20 °C View Scheme

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere 1.2: -78 - 20 °C / Inert atmosphere 2.1: diisobutylaluminium hydride / hexane / 1.5 h / 0 °C / Inert atmosphere 3.1: toluene-4-sulfonic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 - 20 °C / Inert atmosphere 5.1: 4-methylmorpholine N-oxide / dichloromethane / 1 h / 20 °C / Molecular sieve 5.2: 0.67 h / 5 °C 6.1: bis(benzonitrile)palladium(II) dichloride; p-benozquinone / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere 7.1: ozone / methanol / 0.5 h / -78 °C 7.2: 0 - 20 °C View Scheme