4-N-Boc-氨基环己酮合成路线 （共 23 条）
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-60°C; 1.25 h; 2: With triethylamine in dichloromethane T=-60 - 20°C;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1403255 A1, 2004 ;
Location in patent: Page 71 ;
EP 1403255 A1
反应条件
molecular sieves in dichloromethane; ethyl acetate
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1
反应条件
molecular sieves in tetrahydrofuran; sodium hydroxide; dichloromethane
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane T=-78 - 20°C; 1.5 h;
参考文献
Noguchi, Hirohide; Aoyama, Toyohiko; Shioiri, Takayuki
Heterocycles, 2002 , vol. 58, p. 471 - 504
反应条件
triethylamine in dichloromethane; dimethyl sulfoxide
参考文献
US5574044 A1, ;
US 5574044 A
反应条件
in ethyl acetate; Petroleum ether
参考文献
US2013/190249 A1, ;
Page/Page column ;
反应条件
1: 93 percent / aq. NaOH / dioxane / 2 h / 20 °C 2: 98 percent / (COCl)2; Me2SO; Et3N / CH2Cl2 / 1.5 h / -78 - 20 °C View Scheme
参考文献
Heterocycles, , vol. 58, p. 471 - 504
反应条件
1: 95 percent / Et3N / tetrahydrofuran 2: 94 percent / oxalyl chloride; Et3N; DMSO / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 12 p. 3103 - 3107
反应条件
1: triethylamine / methanol; tetrahydrofuran 2: Petroleum ether; ethyl acetate View Scheme
反应条件
sodium hydroxide in water; acetonitrile T=0 - 20°C; 1 h; Inert atmosphere;
参考文献
Sasano, Yusuke; Nagasawa, Shota; Yamazaki, Mai; Shibuya, Masatoshi; Park, Jaiwook; Iwabuchi, Yoshiharu
Angewandte Chemie - International Edition, 2014 , vol. 53, # 12 p. 3236 - 3240
Angew. Chem., 2014 , vol. 126, # 12 p. 3300 - 3304,5
