4-N-Boc-氨基环己酮合成路线 （共 23 条）
反应条件
diethylamino-sulfur trifluoride in dichloromethane
T=-5 - 20°C; Inert atmosphere;
参考文献
AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding
Patent: WO2013/107291 A1, 2013 ;
Location in patent: Page/Page column 64 ;
反应条件
potassium hexamethylsilazane in tetrahydrofuran
T=-78°C; 0.5 h;
参考文献
Kotoku, Naoyuki; Sumii, Yuji; Hayashi, Takeshi; Tamura, Satoru; Kawachi, Takashi; Shiomura, Sho; Arai, Masayoshi; Kobayashi, Motomasa
Medicinal Chemistry letters, 2012 , vol. 3, # 8 p. 673 - 677,5
反应条件
1: Na(AcO)3BH; HOAc / CH2Cl2 / 8 h / 20 °C
2: CF3CO2H / CH2Cl2 / 2 h / 20 °C
View Scheme
参考文献
Li, Shengjian; Chiu, George; Pulito, Virginia L.; Liu, Jingchun; Connolly, Peter J.; Middleton, Steven A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1646 - 1650
