1-(4-碘苯基)-2-甲基-1H-咪唑合成路线 （共 3 条）
反应条件
1: 2-methyl-1H-imidazole With sodium hydride in N,N-dimethyl-formamide T=20°C; 0.5 h; 2: 4-fluoro-1-iodobenzene in N,N-dimethyl-formamide T=100°C; 16 h;
参考文献
Mano, Takashi; Stevens, Rodney W.; Ando, Kazuo; Kawai, Makoto; Kawamura, Kiyoshi; Nakao, Kazunari; Okumura, Yoshiyuki; Okumura, Takako; Sakakibara, Minoru; Miyamoto, Kimitaka; Tamura, Tetsuya
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 8 p. 965 - 973
反应条件
in water; N,N-dimethyl-formamide; mineral oil
反应条件
1: 0.90 g / Pd(PPh3)4; t-BuONa / Heating
2: 488 mg / aq. LiOH / methanol; tetrahydrofuran / 11 h / Heating
3: oxalyl chloride / CH2Cl2 / 0.83 h / 0 - 20 °C
4: 207 mg / aq. NH3 / 1 h
View Scheme
参考文献
Mano, Takashi; Stevens, Rodney W.; Ando, Kazuo; Kawai, Makoto; Kawamura, Kiyoshi; Nakao, Kazunari; Okumura, Yoshiyuki; Okumura, Takako; Sakakibara, Minoru; Miyamoto, Kimitaka; Tamura, Tetsuya
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 8 p. 965 - 973
