4-[4-(乙氧基羰基)哌啶]苯甲酸合成路线 （共 3 条）
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine in 1,4-dioxane T=120°C; 96 h; 2: With palladium 10 on activated carbon; hydrogen in ethanol P=760.051 Torr; Sealed tube;
参考文献
Madrigal Pharmaceuticals, Inc.; BOLIN, David, R.; CHEUNG, Adrian, Wai-hing; HAMILTON, Matthew, Michael; MARCOPULOUS, Nicholas; McDERMOTT, Lee, Apostle; QIAN, Yimin
Patent: EP2350311 B1, 2013 ;
Location in patent: Paragraph 0107 ;
反应条件
1: With morpholine; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=60°C; 1.5 h; 2: With sodium hydrogencarbonate in water; ethyl acetate 3: With hydrogenchloride in water
参考文献
YAMANOUCHI PHARMACEUTICAL CO. LTD.
Patent: EP1466912 A1, 2004 ;
Location in patent: Page 28 ;
反应条件
1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane; diethyl ether 2.1: N-ethyl-N,N-diisopropylamine; 4-(N,N-dimethlyamino)pyridine / 1,4-dioxane / 96 h / 120 °C 2.2: 760.05 Torr / |Sealed tube View Scheme
参考文献
Madrigal Pharmaceuticals, Inc.; BOLIN, David, R.; CHEUNG, Adrian, Wai-hing; HAMILTON, Matthew, Michael; MARCOPULOUS, Nicholas; McDERMOTT, Lee, Apostle; QIAN, Yimin
Patent: EP2350311 B1, 2013 ;
