(2S)-2-氨基-3-苯基丙酸乙酯合成路线 （共 27 条）
反应条件
Alcalase; 3,5-dichloro-benzaldehyde in water; acetonitrile T=35°C; pH=7.5; 120 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Schichl, Daniel A.; Enthaler, Stephan; Holla, Wolfgang; Riermeier, Thomas; Kragl, Udo; Beller, Matthias
European Journal of Organic Chemistry, 2008 , # 20 p. 3506 - 3512
反应条件
water T=25°C; 0.166667 h; Microbiological reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Stella, Selvaraj; Chadha, Anju
Tetrahedron Asymmetry, 2010 , vol. 21, # 4 p. 457 - 460
反应条件
phosphate buffer; Humicola amino esterase
Ambient temperature; Title compound not separated from byproducts;
参考文献
Bruening, Ronald L.; Krakowiak, Krzysztof E.
Patent: US2004/132998 A1, 2004 ;
Location in patent: Page 10-11 ;
反应条件
in tetrahydrofuran
T=-10°C; 12 h; Title compound not separated from byproducts.;
参考文献
Karnik, Anil V.; Kamath, Suchitra S.
Journal of Organic Chemistry, 2007 , vol. 72, # 19 p. 7435 - 7438
反应条件
water
T=25°C; 0.166667 h; Microbiological reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Stella, Selvaraj; Chadha, Anju
Tetrahedron Asymmetry, 2010 , vol. 21, # 4 p. 457 - 460
反应条件
1: 100 percent / K2CO3 / diethyl ether; H2O / ice bath
2: sodium ethanolate / ethanol; diethyl ether / 15 h / Ambient temperature
3: 90 percent / acetonitrile; H2O / 2 h / 70 °C
4: 75 percent / sodium cyanoborohydride, chloroacetic acid / methanol / 1 h / Ambient temperature
View Scheme
参考文献
Vedejs; Campbell Jr.; Gadwood; et al.
Journal of Organic Chemistry, 1982 , vol. 47, # 8 p. 1534 - 1546
反应条件
1: F2; MeCN; H2O / CH2Cl2 / 0 °C
2: aq. tetrabutylammonium hydroxide / CH2Cl2 / 48 h / 20 °C
3: 90 percent / H2 / Pd/C / methanol / 12 h / 20 °C
View Scheme
参考文献
Harel, Tal; Rozen, Shlomo
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6500 - 6503
反应条件
2: aq.-ethanolic NaOH
View Scheme
参考文献
Fones
Journal of Organic Chemistry, 1952 , vol. 17, p. 1661,1662
反应条件
diethyl ether; potassium hydrogencarbonate
Behandeln des Reaktionsprodukts mit wss.-aethanol. Natronlauge;
参考文献
Neurath; Elkins; Kaufman
Journal of Biological Chemistry, 1947 , vol. 170, p. 221,222
反应条件
phosphorus trichoride
参考文献
Goldschmidt; Lautenschlager
Justus Liebigs Annalen der Chemie, 1953 , vol. 580, p. 68,78
