6-甲氧基-1,2,3,4-四氢-9H-吡啶并[3,4-b]吲哚-1-甲酸合成路线 （共 3 条）
反应条件
potassium hydroxide T=20°C; Pictet-Spengler reaction; 1 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 22 p. 5840 - 5843
反应条件
hydrogenchloride T=100°C;
参考文献
Schott, Yvonne; Decker, Michael; Rommelspacher, Hans; Lehmann, Jochen
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5840 - 5843
反应条件
1: 97 percent / HCl / Ambient temperature
2: 77 percent / conc. aq. NH4OH / Ambient temperature
3: 70 percent / 5percent Pd/C / xylene / 2 h / Heating
4: 65 percent / POCl3, pyridine / dimethylformamide / 1 h / 0 °C
5: 75 percent / tetrahydrofuran / 2 h / Ambient temperature
6: 69 percent / ammonium acetate / acetic acid / 3 h / Heating
7: 72 percent / boron tribromide / CH2Cl2; 1,2-dichloro-ethane / 0.5 h / Heating
View Scheme
参考文献
Rinehart,K.B.; Kobayashi,J.; Harbour,G.C.
Journal of the American Chemical Society, 1987 , vol. 109, p. 3378
