2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-1-酮合成路线 （共 43 条）
反应条件
1.1: sodium carbonate / chloroform
2.1: polyphosphoric acid / 1 h / 120 °C
2.2: Cooling with ice
View Scheme
参考文献
NOVARTIS AG; BOCK, Mark G.; GAUL, Christoph; GUMMADI, Venkateshwar Rao; MOEBITZ, Henrik; SENGUPTA, Saumitra
Patent: WO2012/35078 A1, 2012 ;
WO 2012/035078 A1
反应条件
1.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
1.2: 0 - 20 °C / Reflux; Inert atmosphere
2.1: sulfuric acid; acetic acid / 2.5 h / Reflux; Inert atmosphere
View Scheme
参考文献
XUE, LIANG; Chan, William K.; Linnet, Stan W.; Linnet, Timothy N.
Patent: US2012/322816 A1, 2012 ;
反应条件
hydrogen bromide; triethylamine
1.) toluene, r.t., 20 min, 2.) acetic acid, reflux, 30 min; Yield given. Multistep reaction;
参考文献
Bracher, Franz; Hildebrand, Dirk
Liebigs Annalen der Chemie, 1992 , # 12 p. 1315 - 1320
反应条件
in acetic acid
72 h; Heating;
参考文献
Kalaus, Gyoergy; Gyoery, Peter; Kajtar-Peredy, Maria; Radics, Lajos; Szabo, Lajos; Szantay, Csaba
Chemische Berichte, 1981 , vol. 114, # 4 p. 1476 - 1483
反应条件
1: 96 percent / ethanol; CH2Cl2 / 0.25 h / Heating
2: 56 percent / formic acid / 0.33 h / Heating
View Scheme
参考文献
Herdeis, Claus; Bissinger, Gerhard
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 6 p. 785 - 790
反应条件
1: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1.) CH2Cl2, 15 min, 2.) room temperature
2: 96 percent / ethanol; CH2Cl2 / 0.25 h / Heating
3: 56 percent / formic acid / 0.33 h / Heating
View Scheme
参考文献
Herdeis, Claus; Bissinger, Gerhard
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1987 , vol. 42, # 6 p. 785 - 790
反应条件
1: chloroform-d1 / 96 h / 26 °C
2: water / acetonitrile
View Scheme
参考文献
Milena, Matyas; Abranyi-Balogha, Peter; Dancso, Andras; Simig, Gyula; Keglevich, Gyoergy
Letters in Organic Chemistry, 2010 , vol. 7, # 5 p. 377 - 382
反应条件
water in acetonitrile
参考文献
Milena, Matyas; Abranyi-Balogha, Peter; Dancso, Andras; Simig, Gyula; Keglevich, Gyoergy
Letters in Organic Chemistry, 2010 , vol. 7, # 5 p. 377 - 382
反应条件
1: triethylamine / dichloromethane / 26 °C
2: chloroform-d1 / 96 h / 26 °C
3: water / acetonitrile
View Scheme
参考文献
Milena, Matyas; Abranyi-Balogha, Peter; Dancso, Andras; Simig, Gyula; Keglevich, Gyoergy
Letters in Organic Chemistry, 2010 , vol. 7, # 5 p. 377 - 382
反应条件
1: trichlorophosphate
2: triethylamine / dichloromethane / 26 °C
3: chloroform-d1 / 96 h / 26 °C
4: water / acetonitrile
View Scheme
参考文献
Milena, Matyas; Abranyi-Balogha, Peter; Dancso, Andras; Simig, Gyula; Keglevich, Gyoergy
Letters in Organic Chemistry, 2010 , vol. 7, # 5 p. 377 - 382
