6-氯-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-1-酮合成路线 （共 7 条）
反应条件
formic acid 1 h; Heating;
参考文献
Guengoer, Timur; Malabre, Patrice; Teulon, Jean-Marie; Camborde, Francoise; Meignen, Joelle; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4307 - 4316
反应条件
1: H2 / Raney Ni / ethanol / 6 h / 80 °C / 58840.6 Torr 2: 1.) aq. KOH, 2.) aq. CH3COOH / 1.) RT, overnight, 2.) 0 deg C, 4 h 3: 87 percent / 90percent aq. HCOOH / 1 h / Heating View Scheme
参考文献
Guengoer, Timur; Malabre, Patrice; Teulon, Jean-Marie; Camborde, Francoise; Meignen, Joelle; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4307 - 4316
反应条件
1: 1.) aq. KOH, 2.) aq. CH3COOH / 1.) RT, overnight, 2.) 0 deg C, 4 h 2: 87 percent / 90percent aq. HCOOH / 1 h / Heating View Scheme
参考文献
Abramovitch
Journal of the Chemical Society, 1956 , p. 4593,4597
反应条件
1.1: NaNO2; HCl / 0 °C 1.2: acetic acid / 0 °C 2.1: formic acid / 1 h / 100 °C View Scheme
参考文献
Baruah, Bipul; Dasu, Kavitha; Vaitilingam, Balasubramanian; Mamnoor, Premkumar; Venkata, Prasanthi Penubaka; Rajagopal, Sriram; Yeleswarapu, Koteswar Rao
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 1991 - 1994
反应条件
1.1: NaNO2; HCl / 0 °C 1.2: acetic acid / 0 °C 2.1: formic acid / 1 h / 100 °C View Scheme
参考文献
Baruah, Bipul; Dasu, Kavitha; Vaitilingam, Balasubramanian; Mamnoor, Premkumar; Venkata, Prasanthi Penubaka; Rajagopal, Sriram; Yeleswarapu, Koteswar Rao
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 1991 - 1994
反应条件
1: aq.-ethanolic KOH 2: concentrated aqueous HCl; acetic acid View Scheme
参考文献
Abramovitch
Journal of the Chemical Society, 1956 , p. 4593,4597
反应条件
1: 100 percent / KOH / ethanol / 6 h / Heating 2: 72 percent / 10percent aq. HCl / 2 h / Heating View Scheme
参考文献
Guengoer, Timur; Malabre, Patrice; Teulon, Jean-Marie; Camborde, Francoise; Meignen, Joelle; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4307 - 4316
