1,2-二氢-2-氰基喹啉-1-羧酸乙酯合成路线 （共 15 条）
反应条件
1: Irradiation
2: 90 percent / LDA / tetrahydrofuran / -78 deg C, 5 min, RT
3: 84 percent / potassium carbonate / methanol / 0.92 h / Ambient temperature
4: 80 percent / phosphorous oxychloride / 1 h / Ambient temperature
5: 30 percent / NH3 / methanol / Ambient temperature
View Scheme
参考文献
Takeda; Shudo; Okamoto; Kosuge
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 5 p. 1280 - 1285
反应条件
1: Irradiation
2: 55 percent / LDA / tetrahydrofuran / -78 °C
3: 90 percent / K2CO3 / methanol / Ambient temperature
4: 47 percent / phosphorous oxychloride / 1 h / Ambient temperature
5: 88 percent / NH3 / methanol / Ambient temperature
View Scheme
参考文献
Takeda; Shudo; Okamoto; Kosuge
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 5 p. 1280 - 1285
反应条件
1: Irradiation
2: 55 percent / LDA / tetrahydrofuran / -78 °C
3: 90 percent / K2CO3 / methanol / Ambient temperature
4: 12 percent / aluminum chloride / 12 h / 100 - 120 °C
View Scheme
参考文献
Takeda; Shudo; Okamoto; Kosuge
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 5 p. 1280 - 1285
反应条件
sodium hydride in N,N-dimethyl-formamide
2 h; Ambient temperature;
参考文献
Uff, Barrie C.; Budhram, Ronald S.; Ghaem-Maghami, Ghobad; Mallard, Angela S.; Harutunian, Vahak; et al.
Journal of Chemical Research, Miniprint, 1986 , # 6 p. 1901 - 1930
参考文献
Takeda; Shudo; Okamoto; Kosuge
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 5 p. 1280 - 1285
