反应条件
<b>Multi-step reaction with 7 steps<br /> </b>1: Et<sub>3</sub>N / CH<sub>2</sub>Cl<sub>2</sub> / 1.) 0 deg C, 30 min, 2.) RT, 1 h<br />2: 1.) NaH, 2.) KI / 1.) DMF, THF, RT, 15 min, 2.) DMF, THF, 80 deg C, 3.5 h<br />3: 86 percent / DMSO, NaCl / H<sub>2</sub>O / 3 h / 170 °C<br />4: 96 percent / LiAlH<sub>4</sub> / diethyl ether / 15 h / Ambient temperature<br />5: Et<sub>3</sub>N / CH<sub>2</sub>Cl<sub>2</sub> / 1.) 0 deg C, 30 min, 2.) RT, 1 h<br />6: 1.) NaH, 2.) KI / 1.) DMF, THF, RT, 15 min, 2.) DMF, THF, 80 deg C, 3.5 h<br />7: 89 percent / DMSO, NaCl / H<sub>2</sub>O / 3 h / 170 °C<br /> <br />
参考文献
Kaga, Harumi; Goto, Kouhei; Takahashi, Tomiki; Hino, Masao; Tokuhashi, Takashi; Orito, Kazuhiko Tetrahedron, 1996 , vol. 52, # 25 p. 8451 - 8470
