1.1: 101.5 g / DIPEA / acetonitrile / 24 h / 70 °C 2.1: 93.7 percent / TFA / CH2Cl2 / 70 h / 20 °C 3.1: TEA; DCC / CH2Cl2 / 20 h / 20 °C 4.1: hydroxylamine / ethanol; tetrahydrofuran / 3 h / 20 °C / pH 6.0 5.1: ethanol; H2O / Heating 6.1: 54 g / DIPEA / CH2Cl2 / 2 h / -40 °C 7.1: LHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h / -78 °C 7.2: 63.3 percent / 2 h 8.1: 4.5 g / DIPEA; DMAP / CH2Cl2 / -23 - 20 °C 9.1: 1.53 g / DBU / toluene / 0 - 50 °C 10.1: 30 percent / DDQ / CH2Cl2; H2O / 20 °C 11.1: 2 mg / TFA / CH2Cl2 / 0 - 20 °C View Scheme