6,7-二甲氧乙氧基喹唑啉-4-酮合成路线 （共 24 条）
反应条件
T=165 - 170°C; 12 h;
参考文献
Knesl, Petr; Roeseling, Dirk; Jordis, Ulrich
Molecules, 2006 , vol. 11, # 4 p. 286 - 297
反应条件
in 2-methoxy-ethanol T=125°C; 8 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 43, # 7 p. 1478 - 1488
反应条件
1.1: acetic anhydride / 110 °C 2.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 3.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 3.2: 81 percent / HCl / H2O / 90 - 130 °C View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 2.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 2.2: 81 percent / HCl / H2O / 90 - 130 °C View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1.1: hydroxylamine hydrochloride; pyridine / methanol / Heating 2.1: acetic anhydride / 110 °C 3.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 4.2: 81 percent / HCl / H2O / 90 - 130 °C View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1.1: 98 percent / potassium carbonate / dimethylformamide / 100 °C 2.1: hydroxylamine hydrochloride; pyridine / methanol / Heating 3.1: acetic anhydride / 110 °C 4.1: 85 percent / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 5.2: 81 percent / HCl / H2O / 90 - 130 °C View Scheme
参考文献
Heterocycles, , vol. 71, # 1 p. 39 - 48
反应条件
1: nitric acid; acetic anhydride; acetic acid / acetic acid / 0 - 5 °C 2: hydrogen / ethanol 3: ethanol / Reflux View Scheme
参考文献
Medicinal Chemistry, , vol. 7, # 4 p. 295 - 300
反应条件
1: hydrogen / ethanol 2: ethanol / Reflux View Scheme
参考文献
Medicinal Chemistry, , vol. 7, # 4 p. 295 - 300
反应条件
in 2-methoxy-ethanol 24 h; Heating / reflux;
参考文献
WO2006/84882 A2, ;
Page/Page column 12 ;
WO 2006/084882 A2
参考文献
Pandey, Anjali; Scarborough, Robert M; Matsuno, Kenji; Ichimura, Michio; Nomoto, Yuji; Ide, Shinichi; Tsukuda, Eiji; Sasaki, Junko; Oda, Shoji
Patent: US2004/259881 A1, 2004 ;
US 20040259881 A1
