6,7-二甲氧乙氧基喹唑啉-4-酮合成路线 （共 24 条）
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate in toluene Heating;
参考文献
Tetrahedron Letters, , vol. 47, # 15 p. 2539 - 2542
反应条件
1: 6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one With triethylamine; trichlorophosphate in toluene T=20 - 65°C; Inert atmosphere; 2: meta-aminophenylacetylene in isopropyl alcohol; toluene 2.5 h; Inert atmosphere;
参考文献
US2010/267949 A1, ;
Page/Page column 7 ;
反应条件
1.1: trichlorophosphate / N,N-dimethyl-formamide / 0.5 h / 80 °C 1.2: 0.5 h / 0 - 40 °C 2.1: toluene; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 2.2: 4 h / 20 °C View Scheme
反应条件
1.1: 95 percent / P2S5 / pyridine / 24 h / Heating 2.1: aq. NaOH / methanol / 0.5 h / 20 °C 2.2: 86 percent / methanol; H2O / 5 h / 25 °C 3.1: 90 percent / 3-ethynylaniline / propan-2-ol / 15 h / Heating View Scheme
参考文献
Knesl, Petr; Roeseling, Dirk; Jordis, Ulrich
Molecules, 2006 , vol. 11, # 4 p. 286 - 297
