(3alpha,5beta,7alpha,8xi,9xi,14xi,17xi)-3,7-二羟基胆甾烷-26-酸合成路线 (共 2 条)
反应条件
rat liver homogenate, NAD, pH=8.5;
参考文献
Kobayashi; Hagiwara; Morisaki; Yuri; Fujimoto
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 7 p. 1536 - 1538
反应条件
Multi-step reaction with 5 steps 1: H2SO4 2: 420 mg / pyridine / benzene / 18 h / Ambient temperature3: 340 mg / CrO3, aq. H2SO4 / acetone / 0.5 h / Ambient temperature4: 230 mg / acetic acid / 18 h / Ambient temperature5: 1.) NaBH4, CH3COOH, 2.) 10percent aq. NaOH / 1.) a) 50 deg C, 1 h, b) RT, 6 h, 2.) methanol, reflux, 3 h
参考文献
Batta, Ashok K.; Mirchandani, Renu; Salen, Gerald; Shefer, Sarah Steroids, 1992 , vol. 57, # 4 p. 162 - 166