3-甲氧基-雌甾-2,5(10)-二烯-17-酮合成路线 （共 7 条）
反应条件
1: With 2,6-di-tert-butyl-4-methyl-phenol; cyclohexanone; aluminum isopropoxide in toluene T=108 - 110°C; 1 h; 2: With water in toluene T=20 - 25°C; 1 h;
参考文献
RICHTER GEDEON VEGYESZETI GYAR RT.
Patent: WO2007/66158 A2, 2007 ;
Location in patent: Page/Page column 8 ;
反应条件
acetic acid in tetrahydrofuran; water T=20°C;
参考文献
HEYL CHEMISCH-PHARMAZEUTISCHE FABRIK GMBH and CO. KG
Patent: US2010/298585 A1, 2010 ;
Location in patent: Page/Page column 3 ;
反应条件
2: 63 percent / aluminium isopropylate, 2-butanone / benzene / 15 h View Scheme
参考文献
Helvetica Chimica Acta, , vol. 68, # 4 p. 1054 - 1068
反应条件
methanol; acetic acid
参考文献
Searle and Co.
Patent: US2729654 , 1954 ;
参考文献
Searle and Co.
Patent: US2838530 , 1957 ;
反应条件
sulfinylcarbamic acid ethyl ester in dichloromethane 3 h; Ambient temperature;
参考文献
Solyom; Szilagyi; Toldy
1983 , vol. No. 6, p. 1001 - 1019
反应条件
hydrogenchloride; potassium tert-butylate 1.) THF, 1 h, -10 deg C; 2.) MeOH, 60-70 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Baier; Durner; Quinkert
Helvetica Chimica Acta, 1985 , vol. 68, # 4 p. 1054 - 1068
