反应条件
1: thionyl chloride; N,N-dimethyl-formamide / toluene / 15 h / 20 °C
2: trimethylamine / dichloromethane / 0 - 20 °C
3: hydrogenchloride / water; acetic acid / 20 °C
4: palladium 10 on activated carbon; hydrogen / acetic acid / 8 h / 3102.97 Torr
5: borane-THF / tetrahydrofuran / 0 °C / Reflux
View Scheme
参考文献
Wang, Min; Gao, Mingzhang; Steele, Brandon L.; Glick-Wilson, Barbara E.; Brown-Proctor, Clive; Shekhar, Anantha; Hutchins, Gary D.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4713 - 4718