5-氟-2-甲氧基苯硼酸合成路线 （共 11 条）
反应条件
1: 2-bromo-4-fluoro-1-methoxy-benzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1.33333 h; Inert atmosphere; 2: boric acid trimethyl ester in tetrahydrofuran; hexane T=20°C; Inert atmosphere;
参考文献
EXXONMOBIL CHEMICAL PATENTS INC.; RAMOT AT TEL-AVIV UNIVERSITY LTD.; GIESBRECHT, Garth, R.; HOLTCAMP, Matthew, W.; KOL, Moshe; DAY, Gregory S.; PRESS, Konstantin
Patent: WO2014/22011 A1, 2014 ;
Location in patent: Page/Page column 47; 48 ;
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran
参考文献
US5688810 A1, ;
US 5688810 A
US5693647 A1, ;
反应条件
1: With n-butyllithium in tetrahydrofuran; cyclohexane T=-60°C; 5 h; 2: With tri-isopropoxy-borane in tetrahydrofuran; cyclohexane T=-70 - 20°C;
参考文献
Audouze, Karine; Nielsen, Elsebet stergaard.; Peters, Dan
Journal of Medicinal Chemistry, 2004 , vol. 47, # 12 p. 3089 - 3104
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran
参考文献
US5688808 A1, ;
US 5688808 A
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethanol; toluene T=50°C; 16 h;
参考文献
US2009/54466 A1, ;
Page/Page column 84-86 ;
US 20090054466 A1
反应条件
dihydrogen peroxide in ethanol 2 h; Heating;
参考文献
Audouze, Karine; Nielsen, Elsebet stergaard.; Peters, Dan
Journal of Medicinal Chemistry, 2004 , vol. 47, # 12 p. 3089 - 3104
反应条件
in dichloromethane; water
参考文献
Axys Pharmaceuticals, Inc.
Patent: US2003/114457 A1, 2003 ;
US 20030114457 A1
反应条件
boron tribromide in dichloromethane T=0°C; 0.25 h; Inert atmosphere;
参考文献
Friedman, Adam A.; Panteleev, Jane; Tsoung, Jennifer; Huynh, Vaizanne; Lautens, Mark
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9755 - 9758
反应条件
1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 24 h / 80 °C 2: tert-butyl alcohol; sodium chlorite; sodium dihydrogenphosphate / tetrahydrofuran; water / 3 h / 20 °C View Scheme
参考文献
Demuner, Antonio Jacinto; Barbosa, Luiz Claudio Almeida; Miranda, Ana Cristina Mendes; Geraldo, Guilherme Carvalho; Da Silva, Cleiton Moreira; Giberti, Samuele; Bertazzini, Michele; Forlani, Giuseppe
Journal of Natural Products, 2013 , vol. 76, # 12 p. 2234 - 2245
反应条件
1: boron tribromide / dichloromethane / 0.25 h / 0 °C / |Inert atmosphere
2: diethyl ether / 20 °C / |Inert atmosphere
View Scheme
参考文献
Friedman, Adam A.; Panteleev, Jane; Tsoung, Jennifer; Huynh, Vaizanne; Lautens, Mark
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9755 - 9758
