7-氨基-1,2,3,4-四氢-2,2-二甲基喹啉合成路线 （共 4 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol; ethyl acetate 6 h;
参考文献
Ligand Pharmaceuticals Incorporated
Patent: US6017924 A1, 2000 ;
反应条件
1: H2SO4, HNO3 / 10 h / -10 °C 2: H2 / Pd/C / ethyl acetate / 15 h / Ambient temperature View Scheme
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
1: 99 percent / H2 / 10percent Pd/C / ethanol; ethyl acetate / 4 h 2: 57 percent / HNO3, H2SO4 / 0.25 h / -5 °C 3: H2 / 10percent Pd/C / ethanol; ethyl acetate / 6 h View Scheme
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
1: 74 percent / CuCl / tetrahydrofuran / 14 h / Heating 2: 99 percent / H2 / 10percent Pd/C / ethanol; ethyl acetate / 4 h 3: 57 percent / HNO3, H2SO4 / 0.25 h / -5 °C 4: H2 / 10percent Pd/C / ethanol; ethyl acetate / 6 h View Scheme
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
