1: ethyl 2,2,3,3,3-pentafluoropropionate With sodium methylate in methanol; diethyl ether T=0°C; 0.5 h; 2: acetophenone in methanol; diethyl ether T=20°C; Claisen condensation; 16 h; Further stages.;

sodium methylate in diethyl ether

20 h; Ambient temperature;