lithium hydroxide hydrate in tetrahydrofuran; methanol; water T=20°C; 3.5 h;

1: Cu / 40 h / 250 °C 2: (saponification) 3: (i) NaOEt, EtOH, (ii) /BRN= 635704/ 4: PhNEt2 / 4 h / Heating View Scheme

1: Cu / 40 h / 250 °C 2: (saponification) View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: pyridine / dichloromethane / 0.5 h / Cooling with ice<br />2: iodine cloride / dichloromethane / 32 h / 20 &deg;C / Cooling with ice<br /> <br /> &nbsp;