2-三正丁基甲锡烷基吡啶合成路线 （共 97 条）
反应条件
1: 2-bromo-pyridine With n-butyllithium in tetrahydrofuran T=-70°C; 0.5 h; Inert atmosphere; 2: tributyltin chloride in tetrahydrofuran T=-70°C; 2 h;
参考文献
Samumed, LLC; Kumar KC, Sunil; Hood, John
Patent: US2014/194441 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
magnesium; ethylene dibromide in tetrahydrofuran T=35°C; Barbier Coupling Reaction; 1 h; SonicationInert atmosphere; regioselective reaction;
参考文献
Gerbino, Dario C.; Fidelibus, Pablo M.; Mandolesi, Sandra D.; Ocampo, Romina A.; Scoccia, Jimena; Podesta, Julio C.
Journal of Organometallic Chemistry, 2013 , vol. 741-742, # 1 p. 24 - 32
反应条件
ethylbromide in benzene refluxing, 2h;;
参考文献
J. Organometal. chem., , vol. 11, p. 499 - 502
反应条件
1.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere 2.1: water; hydrogen bromide / 3 h / 110 °C 2.2: pH 11 / Cooling with ice 3.1: pyridine; copper diacetate / N,N-dimethyl-formamide / 16 h 4.1: N-bromosuccinmide / N,N-dimethyl-formamide / 4 h / 20 °C 5.1: copper(l) iodide; palladium diacetate; potassium carbonate; triphenylphosphine / ethylene glycol dimethyl ether / 5.5 h / 70 - 95 °C / Inert atmosphere View Scheme
参考文献
Synthesis, , vol. 44, # 1 art. no. M92511SS, p. 57 - 62
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene T=120°C; 72 h;
参考文献
Takizawa, Shin-Ya; Echizen, Hidenori; Nishida, Jun-Ichi; Tsuzuki, Toshimitsu; Tokito, Shizuo; Yamashita, Yoshiro
Chemistry Letters, 2006 , vol. 35, # 7 p. 748 - 749
反应条件
1.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere 2.1: water; hydrogen bromide / 3 h / 110 °C 2.2: pH 11 / Cooling with ice View Scheme
参考文献
Synthesis, , vol. 44, # 1 art. no. M92511SS, p. 57 - 62
反应条件
benzoylchlorobis(triphenylphosphine)palladium(II) in toluene T=110°C; 1 h;
参考文献
Clerici, Francesca; Erba, Emanuela; Gelmi, Maria Luisa; Valle, Marinella
Tetrahedron, 1997 , vol. 53, # 46 p. 15859 - 15866
反应条件
1: 75 percent / PdCl2(PPh3)2 / tetrahydrofuran / 24 h / 110 °C 2: CuSO4, NaBH4 / ethanol; H2O / 3 h / 0 °C 3: 1) conc. HCl, NaNO2, 2) NaN3, NaOAc / 1) H2O, 0 deg C, 1 h, 2) water, 0 deg C, 1 h 4: 90 percent / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Molina; Lorenzo; Aller
Tetrahedron, 1992 , vol. 48, # 22 p. 4601 - 4616
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene 24 h; Inert atmosphereReflux;
参考文献
Kim, Seul-Ong; Zhao, Qinghua; Thangaraju; Kim, Jang Joo; Kim, Yun-Hi; Kwon, Soon-Ki
Dyes and Pigments, 2011 , vol. 90, # 2 p. 139 - 145
