2,4-二甲基 3-氨基-1H-吡咯-2,4-二羧酸合成路线 （共 10 条）
反应条件
sodium methylate in methanol T=20°C; 48 h; Reflux;
参考文献
BIOCRYST PHARMACEUTICALS, INC.; KOTIAN, Pravin, L.; BABU, Yarlagadda, S.
Patent: WO2013/158746 A1, 2013 ;
Location in patent: Page/Page column 88; 89 ;
反应条件
in methanol T=45°C; 5 h; Heating / reflux;
参考文献
BIOCRYST PHARMACEUTICALS, INC.
Patent: US2004/214840 A1, 2004 ;
Location in patent: Page/Page column 2 ;
反应条件
sodium methylate in methanol 48 h; Reflux;
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.; BANTIA, Shanta; WU, Minwan; KUMAR, V., Satish
Patent: WO2014/78778 A2, 2014 ;
Location in patent: Page/Page column 103-104 ;
反应条件
in methanol T=45°C; 25 h; RefluxLarge scale reaction;
参考文献
Kamath, Vivekanand P.; Juarez-Brambila, Jesus J.; Morris, Christopher B.; Winslow, Christopher D.; Morris Jr., Philip E.
Organic Process Research and Development, 2009 , vol. 13, # 5 p. 928 - 932
反应条件
sodium methylate 3 h; Heating;
参考文献
Elliott; Montgomery; Walsh
Tetrahedron Letters, 1996 , vol. 37, # 25 p. 4339 - 4340
反应条件
1: ethanol / |Reflux 2: potassium hydroxide / 40 h / 20 - 60 °C 3: trichlorophosphate / 1 h / |Inert atmosphere; |Reflux 4: sodium hydride / tetrahydrofuran / 2 h / 4 °C / |Inert atmosphere 5: N-bromosuccinmide / dichloromethane / 0.5 h / 0 - 20 °C / |Inert atmosphere; |Heating View Scheme
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.; BANTIA, Shanta; WU, Minwan; KUMAR, V., Satish
Patent: WO2014/78778 A2, 2014 ;
反应条件
1: 57 percent / acetic acid / 14 h / 100 °C 2: 72 percent / 10percent sodium methoxide / methanol / 14 h / 70 °C 3: 54 percent / polyphosphoric acid / 2 h / 180 °C View Scheme
参考文献
Elliott; Montgomery; Walsh
Tetrahedron Letters, 1996 , vol. 37, # 25 p. 4339 - 4340
反应条件
1: ethanol / |Reflux 2: potassium hydroxide / 40 h / 20 - 60 °C View Scheme
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.; BANTIA, Shanta; WU, Minwan; KUMAR, V., Satish
Patent: WO2014/78778 A2, 2014 ;
参考文献
BIOCRYST PHARMACEUTICALS, INC.; KOTIAN, Pravin, L.; BABU, Yarlagadda, S.
Patent: WO2013/158746 A1, 2013 ;
Location in patent: Page/Page column 89 ;
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.; BANTIA, Shanta; WU, Minwan; KUMAR, V., Satish
Patent: WO2014/78778 A2, 2014 ;
Location in patent: Page/Page column 104 ;
