[2-(3-氨基苯基)乙基]氨基甲酸叔丁酯合成路线 （共 6 条）
参考文献
Hah, Jung-Mi; Martasek, Pavel; Roman, Linda J.; Silverman, Richard B.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 9 p. 1661 - 1669
反应条件
1.1: BH3 / tetrahydrofuran / 25 °C 1.2: aq. HCl / tetrahydrofuran / 0 °C 2.1: SnCl2*2H2O / ethanol / 70 °C 3.1: 100 percent / dioxane View Scheme
参考文献
Perez, Daniel; Crespo, Maribel; Sole, Laia; Prat, Maria; Carcasona, Carla; Calama, Elena; Otal, Raquel; Gavalda, Amadeu; Gomez-Angelats, Mireia; Miralpeix, Montserrat; Puig, Carles
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1545 - 1548
反应条件
1: SnCl2*2H2O / ethanol / 70 °C 2: 100 percent / dioxane View Scheme
参考文献
Hah, Jung-Mi; Martasek, Pavel; Roman, Linda J.; Silverman, Richard B.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 9 p. 1661 - 1669
反应条件
1: tetrahydrofuran / 2 h 2: palladium 10 on activated carbon; hydrogen / methanol / 3 h / 20 °C / 1551.49 Torr View Scheme
参考文献
Perez, Daniel; Crespo, Maribel; Sole, Laia; Prat, Maria; Carcasona, Carla; Calama, Elena; Otal, Raquel; Gavalda, Amadeu; Gomez-Angelats, Mireia; Miralpeix, Montserrat; Puig, Carles
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1545 - 1548
反应条件
1: methanol; water / 4 h / 95 °C 2: dimethylsulfide borane complex / tetrahydrofuran / 24 h / 20 °C 3: tetrahydrofuran / 2 h 4: palladium 10 on activated carbon; hydrogen / methanol / 3 h / 20 °C / 1551.49 Torr View Scheme
参考文献
Perez, Daniel; Crespo, Maribel; Sole, Laia; Prat, Maria; Carcasona, Carla; Calama, Elena; Otal, Raquel; Gavalda, Amadeu; Gomez-Angelats, Mireia; Miralpeix, Montserrat; Puig, Carles
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1545 - 1548
反应条件
trifluoroacetic acid T=20°C; 0.5 h;
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: EP2168966 A1, 2010 ;
Location in patent: Page/Page column 61 ;
EP 2168966 A1
