2,4-双(三氟甲基)-6-甲氧基苯甲酸合成路线 （共 6 条）
反应条件
n-butyllithium in diethyl ether 2 h; Ambient temperature;
参考文献
Dmowski, Wojciech; Piasecka-Maciejewska, Krystyna
Journal of Fluorine Chemistry, 1996 , vol. 81, # 1 p. 59 - 63
反应条件
1: 52 percent / HF, SF4 / 20 h / 60 °C 2: 82 percent / KOH / 1.) MeOH, 2.) THF, room temp., overnight; reflux, 3 h 3: 84.2 percent / n-BuLi / diethyl ether / 2 h / Ambient temperature View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 81, # 1 p. 59 - 63
反应条件
1: 82 percent / KOH / 1.) MeOH, 2.) THF, room temp., overnight; reflux, 3 h 2: 84.2 percent / n-BuLi / diethyl ether / 2 h / Ambient temperature View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 81, # 1 p. 59 - 63
反应条件
1: 83 percent / HF, SF4 / 20 h / 140 °C 2: 84.2 percent / n-BuLi / diethyl ether / 2 h / Ambient temperature View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 81, # 1 p. 59 - 63
反应条件
1: KOH / tetrahydrofuran / 1.) room temp., overnight, 2.) reflux, 3 h 2: 95.6 percent / aq. KOH / Heating 3: 83 percent / HF, SF4 / 20 h / 140 °C 4: 84.2 percent / n-BuLi / diethyl ether / 2 h / Ambient temperature View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 81, # 1 p. 59 - 63
反应条件
1: 95.6 percent / aq. KOH / Heating 2: 83 percent / HF, SF4 / 20 h / 140 °C 3: 84.2 percent / n-BuLi / diethyl ether / 2 h / Ambient temperature View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 81, # 1 p. 59 - 63
