螺[异苯并二氢吡喃-1,4’-哌啶]合成路线 （共 5 条）
反应条件
1: With trifluoroacetic acid in dichloromethane T=20°C; 1 h; 2: With sodium carbonate in dichloromethane; water pH=8;
参考文献
PFIZER LIMTED
Patent: WO2006/92731 A1, 2006 ;
Location in patent: Page/Page column 42 ;
WO 2006/092731 A1
反应条件
sodium hydroxide in ethanol 24 h; Heating;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 2 p. 242 - 254
反应条件
1: 1.) n-BuLi / 1.) hexane, THF, Et2O, -78 deg C, 1 h, 2.) hexane, THF, Et2O, RT, 6 h 2: 73 percent / TsCl, pyridine / CH2Cl2 / 38 h / Ambient temperature 3: 5N aq. NaOH / ethanol / 24 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 2 p. 242 - 254
反应条件
1: 1.) n-BuLi / 1.) hexane, THF, Et2O, -78 deg C, 1 h, 2.) hexane, THF, Et2O, RT, 6 h 2: 73 percent / TsCl, pyridine / CH2Cl2 / 38 h / Ambient temperature 3: 5N aq. NaOH / ethanol / 24 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 2 p. 242 - 254
反应条件
1: 73 percent / TsCl, pyridine / CH2Cl2 / 38 h / Ambient temperature 2: 5N aq. NaOH / ethanol / 24 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 2 p. 242 - 254
