3-((叔丁氧基羰基)氨基)-2,2-二甲基丙酸合成路线 （共 6 条）
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=60°C; 16 h;
参考文献
ZALICUS PHARMACEUTICALS LTD .; PAJOUHESH , Hassan; ZHU, Yongbao; ZHOU, Yuanxi; GRIMWOOD, Mike; SIMONSON, Eric
Patent: WO2011/32291 A1, 2011 ;
Location in patent: Page/Page column 47 ;
WO 2011/032291 A1
反应条件
sodium hydroxide in methanol; water T=20°C; 24 h;
参考文献
McCubbin, J. Adam; Maddess, Matthew L.; Lautens, Mark
Organic Letters, 2006 , vol. 8, # 14 p. 2993 - 2996
反应条件
1: With ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile T=20°C; 2: With hydrogenchloride in water
参考文献
EP1548024 A1, ;
Page/Page column 89-90 ;
反应条件
1: H2 / 5 percent Rh/Al2O3 3: NaOH / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 11 p. 1171 - 1173
反应条件
sodium hydroxide in 1,4-dioxane Hydrolysis;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 11 p. 1171 - 1173
反应条件
2: NaOH / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 11 p. 1171 - 1173
