反应条件
1: 53 percent / Ph3P, diethyl azodicarboxylate / tetrahydrofuran / 1.25 h / 0 - 20 °C 2: MCPBA / CH2Cl2 / 18 h / Ambient temperature 3: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature 4: SOCl2 / toluene / 1 h 5: 87 percent / DBU / acetonitrile / 1 h / 50 °C 6: 60 percent / aq. LiOH / methanol; tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Daines, Robert A.; Chambers, Pamela A.; Foley, James J.; Griswold, Don E.; Kingsbury, William D.; Martin, Lenox D.; Schmidt, Dulcie B.; Sham, Kelvin K. C.; Sarau, Henry M.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3837 - 3841
