1,4-二甲基-9H-咔唑合成路线 （共 61 条）
反应条件
in various solvent(s)
T=156°C; 2.5 h; Yields of byproduct given;
参考文献
Pindur, Ulf; Erfanian-Abdoust, Houshang
Liebigs Annalen der Chemie, 1989 , p. 1275 - 1276
反应条件
montmorillonite K-10
T=140°C; Friedel Crafts alkylation; 1 h; Microwave irradiationneat (no solvent);
参考文献
Kulkarni, Aditya; Quang, Phong; Toeroek, Bela
Synthesis, 2009 , # 23 art. no. M02409SS, p. 4010 - 4014
反应条件
1: 87 percent / pyridine
2: 21 percent / 350 °C / 1 - 2 Torr
View Scheme
参考文献
Clancy, Michael G.; Hesabi, Massoud M.; Meth-Cohn, Otto
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 3 p. 429 - 434
反应条件
1: 87 percent / pyridine
2: 21 percent / 350 °C / 1 - 2 Torr
View Scheme
参考文献
Clancy, Michael G.; Hesabi, Massoud M.; Meth-Cohn, Otto
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 3 p. 429 - 434
反应条件
palladium on activated charcoal
1.) 150 deg C, 5 h, 2.) trimethylbenzene, reflux, 3 h; Yield given. Multistep reaction;
参考文献
Mustafin, A. G.; Khalilov, I. N.; Tal'vinskii, E. V.; Abdrakhmanov, I. B.; Spirikhin, L. V.; Tolstikov, G. A.
Chemistry of Natural Compounds, 1992 , vol. 28, # 5 p. 479 - 483
Khimiya Prirodnykh Soedinenii, 1992 , # 5 p. 549 - 554
反应条件
hydrogenchloride; ethanol; sodium acetate
参考文献
Robinson; Saxton
Journal of the Chemical Society, 1952 , p. 976,981
参考文献
Groundwater, Paul W.; Hughes, David; Hursthouse, Michael B.; Lewis, Rhiannon
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 7 p. 669 - 673
参考文献
Robinson; Saxton
Journal of the Chemical Society, 1952 , p. 976,981
反应条件
1: 46 percent / POCl3 / various solvent(s) / 5 h / Heating
2: 82.7 percent / 2 h / 100 °C
3: 74.6 percent / H2 / Raney nickel / ethanol / 24 h / 20 °C / 6080 Torr
View Scheme
参考文献
Vehar, Blaz; Hrast, Martina; Kovac, Andreja; Konc, Janez; Mariner, Katherine; Chopra, Ian; O'Neill, Alex; Janezic, Dusanka; Gobec, Stanislav
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 17 p. 5137 - 5146
反应条件
1: 1,4-dimethyl-9H-carbazole; N,N-dimethyl-formamide With trichlorophosphate in chlorobenzene
T=131°C; 6.5 h;
2: 2,2-diethoxy-ethanamine T=110°C; 4 h;
3: With platinum(IV) oxide; hydrogen in ethanol
T=20°C; P=2585.81 Torr; 72 h;
参考文献
Deane, Fiona M.; Miller, Charlotte M.; Maguire, Anita R.; McCarthy, Florence O.
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 4 p. 814 - 823
