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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
乙炔基胞苷
合成路线
（共 15 条）
199787-45-6
→
反应条件
180300-43-0
乙炔基胞苷
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in methanol T=40°C; 3 h;
参考文献
Nomura, Makoto; Sato, Tsutomu; Washinosu, Masato; Tanaka, Motoaki; Asao, Tetsuji; Shuto, Satoshi; Matsuda, Akira
Tetrahedron, 2002 , vol. 58, # 7 p. 1279 - 1288
848644-38-2
→
反应条件
180300-43-0
乙炔基胞苷
反应条件
ammonia in methanol T=20°C; 46 h;
参考文献
Hrdlicka, Patrick J.; Jepsen, Jan S.; Nielsen, Claus; Wengel, Jesper
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 4 p. 1249 - 1260
180300-42-9
→
反应条件
180300-43-0
乙炔基胞苷
反应条件
ammonia 48 h; Ambient temperature;
参考文献
Hattori, Hideshi; Tanaka, Motohiro; Fukushima, Masakazu; Sasaki, Takuma; Matsuda, Akira
Journal of Medicinal Chemistry, 1996 , vol. 39, # 25 p. 5005 - 5011
1003193-37-0
→
反应条件
180300-43-0
乙炔基胞苷
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 4 h;
参考文献
Ludwig, Peter S.; Schwendener, Reto A.; Schott, Herbert
Synthesis, 2002 , # 16 p. 2387 - 2392
861444-58-8
→
反应条件
180300-43-0
乙炔基胞苷
反应条件
1: trifluoroacetic acid / H2O / 6 h / 20 °C 2: 5.84 g / pyridine; 4-(dimethylamino)pyridine / 40 h / 20 °C 3: 71 percent / N,O-bis(trimethylsilyl)acetamide; trimethylsilyl triflate / acetonitrile / 24 h / 60 °C 4: 74 percent / NH3 / methanol / 46 h / 20 °C View Scheme
参考文献
Hrdlicka, Patrick J.; Jepsen, Jan S.; Nielsen, Claus; Wengel, Jesper
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 4 p. 1249 - 1260
97694-33-2
→
反应条件
180300-43-0
乙炔基胞苷
反应条件
1: 7.17 g / sodium borohydride / methanol / 6.5 h / 20 °C 2: pyridine; 4-(dimethylamino)pyridine / 5 h / 20 °C 3: trifluoroacetic acid / H2O / 6 h / 20 °C 4: 5.84 g / pyridine; 4-(dimethylamino)pyridine / 40 h / 20 °C 5: 71 percent / N,O-bis(trimethylsilyl)acetamide; trimethylsilyl triflate / acetonitrile / 24 h / 60 °C 6: 74 percent / NH3 / methanol / 46 h / 20 °C View Scheme
参考文献
Hrdlicka, Patrick J.; Jepsen, Jan S.; Nielsen, Claus; Wengel, Jesper
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 4 p. 1249 - 1260
97694-32-1
→
反应条件
180300-43-0
乙炔基胞苷
反应条件
1: sodium periodate / methanol; H2O / 15 h / 20 °C 2: 7.17 g / sodium borohydride / methanol / 6.5 h / 20 °C 3: pyridine; 4-(dimethylamino)pyridine / 5 h / 20 °C 4: trifluoroacetic acid / H2O / 6 h / 20 °C 5: 5.84 g / pyridine; 4-(dimethylamino)pyridine / 40 h / 20 °C 6: 71 percent / N,O-bis(trimethylsilyl)acetamide; trimethylsilyl triflate / acetonitrile / 24 h / 60 °C 7: 74 percent / NH3 / methanol / 46 h / 20 °C View Scheme
参考文献
Hrdlicka, Patrick J.; Jepsen, Jan S.; Nielsen, Claus; Wengel, Jesper
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 4 p. 1249 - 1260
35810-59-4
→
反应条件
180300-43-0
乙炔基胞苷
反应条件
1: acetic acid / H2O / 24 h / 20 °C 2: sodium periodate / methanol; H2O / 15 h / 20 °C 3: 7.17 g / sodium borohydride / methanol / 6.5 h / 20 °C 4: pyridine; 4-(dimethylamino)pyridine / 5 h / 20 °C 5: trifluoroacetic acid / H2O / 6 h / 20 °C 6: 5.84 g / pyridine; 4-(dimethylamino)pyridine / 40 h / 20 °C 7: 71 percent / N,O-bis(trimethylsilyl)acetamide; trimethylsilyl triflate / acetonitrile / 24 h / 60 °C 8: 74 percent / NH3 / methanol / 46 h / 20 °C View Scheme
参考文献
Hrdlicka, Patrick J.; Jepsen, Jan S.; Nielsen, Claus; Wengel, Jesper
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 4 p. 1249 - 1260
13089-48-0
苯甲酰胞苷
→
反应条件
180300-43-0
乙炔基胞苷
反应条件
1.1: 82 percent / pyridine / 18 h / 20 °C 2.1: AgNO3; pyridine / tetrahydrofuran / 3 h / 20 °C 3.1: 78 percent / CrO3; pyridine; Ac2O / CH2Cl2 / 1 h / 15 °C 4.1: 76 percent / p-TsOH / methanol; CHCl3 / 0.08 h / 20 °C 5.1: CeCl3; BuLi / tetrahydrofuran; hexane / 2.5 h / -50 °C 5.2: 85 percent / tetrahydrofuran; hexane / 3 h / -65 °C 6.1: ammonia / methanol / 24 h / 20 °C 7.1: 24.6 g / TBAF / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Ludwig, Peter S.; Schwendener, Reto A.; Schott, Herbert
Synthesis, 2002 , # 16 p. 2387 - 2392
65-46-3
胞苷
→
反应条件
180300-43-0
乙炔基胞苷
反应条件
1.1: 96 percent / dioxane; H2O / 4 h / 90 °C 2.1: 82 percent / pyridine / 18 h / 20 °C 3.1: AgNO3; pyridine / tetrahydrofuran / 3 h / 20 °C 4.1: 78 percent / CrO3; pyridine; Ac2O / CH2Cl2 / 1 h / 15 °C 5.1: 76 percent / p-TsOH / methanol; CHCl3 / 0.08 h / 20 °C 6.1: CeCl3; BuLi / tetrahydrofuran; hexane / 2.5 h / -50 °C 6.2: 85 percent / tetrahydrofuran; hexane / 3 h / -65 °C 7.1: ammonia / methanol / 24 h / 20 °C 8.1: 24.6 g / TBAF / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Ludwig, Peter S.; Schwendener, Reto A.; Schott, Herbert
Synthesis, 2002 , # 16 p. 2387 - 2392
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