N-(三甲基硅基)-2-(三甲基硅氧基)-4-嘧啶胺合成路线 （共 18 条）
反应条件
chloro-trimethyl-silane 6 h; Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 19 p. 4332 - 4335
反应条件
ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane Heating;
参考文献
Journal of Organic Chemistry, , vol. 59, # 7 p. 1783 - 1788
反应条件
ammonium sulfate in toluene Reflux;
参考文献
Tetrahedron, , vol. 66, # 30 p. 5687 - 5691
反应条件
in acetonitrile 0.5 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 12 p. 2195 - 2201
反应条件
bis-triphenylphosphine-palladium(II) chloride T=110°C; 72 h; Title compound not separated from byproducts;
参考文献
Journal of Heterocyclic Chemistry, , vol. 28, # 6 p. 1629 - 1631
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 1 p. 142 - 143
反应条件
1.) pyridine, 10 min, reflux. 2.) 4 h, reflux; Multistep reaction;
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 105, p. 528 - 537
反应条件
in diphenylether; n-heptane; ethyl acetate T=130 - 140°C; 8 h; Heating / reflux; Product distribution / selectivity;
参考文献
Hanmi Pharm. Co.,Ltd
Patent: US2007/249818 A1, 2007 ;
Location in patent: Page/Page column 10-11 ;
反应条件
in diphenylether; n-heptane; ethyl acetate T=130 - 140°C; 9 h; Heating / reflux; Product distribution / selectivity;
参考文献
Hanmi Pharm. Co.,Ltd
Patent: US2007/249818 A1, 2007 ;
Location in patent: Page/Page column 8 ;
反应条件
in n-heptane; ethyl acetate T=130 - 140°C; 8 h; Heating / reflux; Product distribution / selectivity;
参考文献
Hanmi Pharm. Co.,Ltd
Patent: US2007/249818 A1, 2007 ;
Location in patent: Page/Page column 7 ;
