1: AcOH / H2O / 48 h / Ambient temperature 2: 90percent H2SO4 / 20 h 3: AcOH / toluene / 20 h / Heating 4: H2, conc. aq. HCl / 5percent Pd/C / methanol / 96 h / 2327.2 Torr 5: Na2CO3 / H2O; dioxane / 20 h / Ambient temperature 6: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h 7: Na2CO3 / methanol; H2O / 3 h / Heating View Scheme

1: 90percent H2SO4 / 20 h 2: AcOH / toluene / 20 h / Heating 3: H2, conc. aq. HCl / 5percent Pd/C / methanol / 96 h / 2327.2 Torr 4: Na2CO3 / H2O; dioxane / 20 h / Ambient temperature 5: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h 6: Na2CO3 / methanol; H2O / 3 h / Heating View Scheme

1: AcOH / toluene / 20 h / Heating 2: H2, conc. aq. HCl / 5percent Pd/C / methanol / 96 h / 2327.2 Torr 3: Na2CO3 / H2O; dioxane / 20 h / Ambient temperature 4: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h 5: Na2CO3 / methanol; H2O / 3 h / Heating View Scheme

1: AcOH / H2O / 48 h / Ambient temperature 2: 90percent H2SO4 / 20 h 3: AcOH / toluene / 20 h / Heating 4: H2, conc. aq. HCl / 5percent Pd/C / methanol / 96 h / 2327.2 Torr 5: Na2CO3 / H2O; dioxane / 20 h / Ambient temperature 6: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h 7: Na2CO3 / methanol; H2O / 3 h / Heating View Scheme

1: H2, conc. aq. HCl / 5percent Pd/C / methanol / 96 h / 2327.2 Torr 2: Na2CO3 / H2O; dioxane / 20 h / Ambient temperature 3: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h 4: Na2CO3 / methanol; H2O / 3 h / Heating View Scheme

sodium carbonate in methanol; water 3 h; Heating;

1: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h 2: Na2CO3 / methanol; H2O / 3 h / Heating View Scheme

1: Na2CO3 / H2O; dioxane / 20 h / Ambient temperature 2: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h 3: Na2CO3 / methanol; H2O / 3 h / Heating View Scheme