螺[1H-茚-1,4-哌啶]-3(2H)-酮合成路线 (共 3 条)
反应条件
1: With tetrabutylammomium bromide; water; trifluoroacetic acid in dichloromethane T=20°C; 4 h; 2: With water in diethyl ether; dichloromethane 3: With potassium hydroxide in water
参考文献
VERTEX PHARMACEUTICALS, INCORPORATED
Patent: WO2006/23852 A2, 2006 ;
Location in patent: Page/Page column 84; 85 ;
WO 2006/023852 A2
反应条件
potassium carbonate in hydrogenchloride; methanol; acetonitrile
反应条件
1: 1.) 9-NBN, 2.) PCC 2: TFA / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 6 p. 663 - 668