potassium hydroxide; water in ethanol Hydrolysis; 24 h; Heating;

1: SOCl2 / 2 h / 20 °C 2: 99 percent / bis(pyridine)iodonium(I) tetrafluoroborate; CF3SO3H / CH2Cl2 / 16 h / 20 °C 3: 90 percent / Et3N / Pd(PPh3)2Cl2-CuI / 3 h / 0 - 20 °C 4: 60 percent / CuI / dimethylformamide / 2.5 h / 100 °C 5: 96 percent / KOH; H2O / ethanol / 24 h / Heating View Scheme

1: 99 percent / bis(pyridine)iodonium(I) tetrafluoroborate; CF3SO3H / CH2Cl2 / 16 h / 20 °C 2: 90 percent / Et3N / Pd(PPh3)2Cl2-CuI / 3 h / 0 - 20 °C 3: 60 percent / CuI / dimethylformamide / 2.5 h / 100 °C 4: 96 percent / KOH; H2O / ethanol / 24 h / Heating View Scheme

1: 90 percent / Et3N / Pd(PPh3)2Cl2-CuI / 3 h / 0 - 20 °C 2: 60 percent / CuI / dimethylformamide / 2.5 h / 100 °C 3: 96 percent / KOH; H2O / ethanol / 24 h / Heating View Scheme

1: 60 percent / CuI / dimethylformamide / 2.5 h / 100 °C 2: 96 percent / KOH; H2O / ethanol / 24 h / Heating View Scheme

copper(I) oxide in quinoline T=230°C; Decarboxylation; 4 h;