反应条件
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 3.33 h / -78 - -30 °C / Inert atmosphere
1.2: 0.83 h / -78 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere
3.1: hydrogenchloride; acetic acid; sodium nitrite / water / 0 - 5 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.5 h / Inert atmosphere
4.2: 16 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Yang, Katherine S.; Budin, Ghyslain; Reiner, Thomas; Vinegoni, Claudio; Weissleder, Ralph
Angewandte Chemie - International Edition, 2012 , vol. 51, # 27 p. 6598 - 6603