3-甲基-4-氟苯甲酸甲酯合成路线 （共 5 条）
反应条件
silver fluoride; Pd(CH2SiMe3)2(cod); cyclohexyl BrettPhos in toluene T=130°C; 18 h; Sealed tube;
参考文献
Massachusetts Institute of Technology
Patent: US2011/15401 A1, 2011 ;
Location in patent: Page/Page column 17 ;
反应条件
hydrogenchloride in water 4 h; Reflux;
参考文献
Bolin, David Robert; Hayden, Stuart; Qian, Yimin; Thakkar, Kshitij Chhabilbhai
Patent: US2011/136792 A1, 2011 ;
Location in patent: Page/Page column 18 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=25°C; 15 h;
参考文献
WO2006/24834 A1, ;
Page/Page column 90 ;
WO 2006/024834 A1
反应条件
sulfuric acid in methanol 4 h; Heating / reflux;
参考文献
WO2006/38734 A1, ;
Page/Page column 50 ;
反应条件
hydrogenchloride; tetrafluoroboric acid; sodium nitrite in water T=0 - 5°C; Sandmeyer reaction;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 15 p. 4416 - 4420
