(R)-3-[(1-甲基-2-吡咯烷基)甲基]-5-[2-(苯磺酰基)乙烯基]-1H-吲哚合成路线 （共 15 条）
反应条件
1: tris-(o-tolyl)phosphine; triethylamine; palladium diacetate / N,N-dimethyl-formamide / 0.25 h / 25 - 120 °C 2: sodium hydroxide; methanol / 60 - 65 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 12 p. 1917 - 1920
反应条件
hydrogen; palladium on activated charcoal in water; acetone Industry scale;
参考文献
Furlong, Patrick Joseph; Kelly, Cornelius Joseph; Ogilvie, Ronald James; Ryan, Vincent
Patent: US2005/20663 A1, 2005 ;
Location in patent: Page 2; 4 ;
反应条件
methanesulfonic acid; 5 palladium on charcoal; hydrogen in water; acetone T=25 - 35°C; P=3800.26 - 4560.31 Torr; 0.0833333 h;
参考文献
Kumar, U. Sampath; Sankar, V. Ravi; Rao, M. Malleswara; Jaganathan; Buchi Reddy
Organic Process Research and Development, 2012 , vol. 16, # 12 p. 1917 - 1920
反应条件
methanesulfonic acid; 5 palladium on charcoal; hydrogen in water; acetone T=25 - 30°C;
参考文献
Organic Process Research and Development, , vol. 16, # 12 p. 1917 - 1920
反应条件
1: With methanesulfonic acid; hydrogen; 5 palladium on charcoal in acetone 2: With ammonia in dichloromethane; water 3: With hydrogen bromide in dichloromethane; water T=20°C; 0.5 h;
参考文献
Madasu, Suri Babu; Vekariya, Nagaji Ambabhai; Hari Kiran; Gupta, Badarinadh; Islam, Aminul; Douglas, Paul S.; Babu, Korupolu Raghu
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1400 - 1405
