3,4-二甲氧基苯基乙酸乙酯合成路线 （共 32 条）
反应条件
1: AlCl3; CS2 2: ethanolic sodium ethylate; air View Scheme
参考文献
Bentley et al.
Journal of the Chemical Society, 1952 , p. 1763,1766
反应条件
1: LiAlH4
3: acetone; NaI
View Scheme
参考文献
Barash; Osbond
Journal of the Chemical Society, 1959 , p. 2157,2163
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide in tetrahydrofuran
T=-75°C; 18 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/56365 A2, 2004 ;
Location in patent: Page/Page column 159 ;
反应条件
1: sodium ethylate
2: aq.-ethanolic HCl
View Scheme
参考文献
Takano
Yakugaku Zasshi, 1959 , vol. 79, p. 1449
Chem.Abstr., 1960 , p. 6630
反应条件
sodium hydride in diethyl ether; N,N-dimethyl-formamide
6 h; Ambient temperature;
参考文献
Gatta; Settimj
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 5 p. 1267 - 1270
反应条件
1: 64 percent / NaH / dimethylformamide; diethyl ether / 6 h / Ambient temperature
2: 77 percent / LiAlH4 / diethyl ether / 3 h / Heating
View Scheme
参考文献
Gatta; Settimj
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 5 p. 1267 - 1270
反应条件
1: (3,4-dimethoxyphenyl)acetic acid ethyl ester With lithium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 1 h; Inert atmosphere;
2: [(Cyanocarbonyl)oxy]ethane in tetrahydrofuran
T=-78 - 20°C; Inert atmosphere;
参考文献
Rios-Lombardia, Nicolas; Busto, Eduardo; Garcia-Urdiales, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Journal of Organic Chemistry, 2009 , vol. 74, # 6 p. 2571 - 2574
反应条件
sodium ethanolate in toluene
Heating;
参考文献
Shafik; Ibrahim; El-Khawass; El-Hawash; El-Dardiry
Pharmazie, 1989 , vol. 44, # 2 p. 115 - 118
反应条件
sodium ethanolate in ethanol
1) 20 deg C, 15 h, 2) 1 h, reflux;
参考文献
Shafik; Ibrahim; El-Khawass; El-Hawash; El-Dardiry
Pharmazie, 1989 , vol. 44, # 2 p. 115 - 118
反应条件
nitric acid in acetic acid
T=0°C; 1 h; Yield given;
参考文献
Swenton,J.S.; Bonke,B.R.; Chen,C-P.
Journal of Organic Chemistry, 1989 , vol. 54, p. 51
