4-叠氮基哌啶-1-羧酸叔丁酯合成路线 （共 11 条）
反应条件
sodium azide in N,N-dimethyl-formamide T=80°C; 8 h;
参考文献
Sangshetti, Jaiprakash N.; Nagawade, Rahul R.; Shinde, Devanand B.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 13 p. 3564 - 3567
反应条件
sodium azide in N,N-dimethyl-formamide T=60°C;
参考文献
Moore, Kevin W.; Bonner, Katrine; Jones, Elizabeth A.; Emms, Frances; Leeson, Paul D.; Marwood, Rosemary; Patel, Shil; Patel, Smita; Rowley, Michael; Thomas, Steven; Carling, Robert W.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 9 p. 1285 - 1290
反应条件
nicotinoyl azide; triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=20°C; Mitsunobu reaction; 3 h;
参考文献
Papeo, Gianluca; Posteri, Helena; Vianello, Paola; Varasi, Mario
Synthesis, 2004 , # 17 p. 2886 - 2892
反应条件
1: sodium tetrahydroborate / ethanol / 2 h / 20 °C 2: triethylamine / dichloromethane 3: sodium azide / N,N-dimethyl-formamide / 8 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 1 p. 444 - 448
European Journal of Medicinal Chemistry, , vol. 46, # 4 p. 1040 - 1044
反应条件
1: DIPEA / CH2Cl2 2: NaN3 / dimethylformamide / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 18 p. 2475 - 2479
反应条件
1: DIPEA / CH2Cl2 2: NaN3 / dimethylformamide / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 18 p. 2475 - 2479
反应条件
1: hydrogenchloride / 1,4-dioxane / 60 °C 2: potassium carbonate / dimethyl sulfoxide / 18 h / 90 °C 3: hydrogen; 10 platinum on carbon / tetrahydrofuran / 30 °C / |Flow reactor View Scheme
参考文献
ACS Combinatorial Science, , vol. 15, # 9 p. 503 - 511
反应条件
ammonium hydroxide; triphenylphosphine in 1,4-dioxane; methanol T=27 - 28°C; 0.5 h;
参考文献
Srivastava, Brijesh Kumar; Soni, Rina; Patel, Jayendra Z.; Solanki, Manish; Valani, Darshan; Gupta, Sunil; Mishra, Bhupendra; Takale, Vijay; Pandya, Purvi; Jain, Mukul R.; Patel, Pankaj R.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 18 p. 5227 - 5232
反应条件
1: hydrogenchloride / 1,4-dioxane / 60 °C 2: potassium carbonate / dimethyl sulfoxide / 18 h / 90 °C 3: hydrogen; 10 platinum on carbon / methanol / 30 °C / |Flow reactor View Scheme
参考文献
Bryan, Marian C.; Hein, Christopher D.; Gao, Hua; Xia, Xiaoyang; Eastwood, Heather; Bruenner, Bernd A.; Louie, Steven W.; Doherty, Elizabeth M.
ACS Combinatorial Science, 2013 , vol. 15, # 9 p. 503 - 511
反应条件
1: H2 / 10 percent Pd/C / methanol / 2068.59 Torr 2: DIPEA / CH2Cl2 / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 18 p. 2475 - 2479
