6-甲氧基-1,4-二甲基-9H-咔唑-3-甲醛合成路线 （共 9 条）
反应条件
1: N-methyl-N-formyl-aniline With trichlorophosphate in 1,2-dichloro-benzene T=20°C; Vilsmeier-Haack reaction; 1.5 h; 2: 1,4-dimethyl 6-methoxy 9H-carbazole in 1,2-dichloro-benzene T=105°C; Vilsmeier-Haack reaction; 4 h; 3: With water; sodium acetate in 1,2-dichloro-benzene T=20°C;
参考文献
Vehar, Blaz; Hrast, Martina; Kovac, Andreja; Konc, Janez; Mariner, Katherine; Chopra, Ian; O'Neill, Alex; Janezic, Dusanka; Gobec, Stanislav
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 17 p. 5137 - 5146
反应条件
trichlorophosphate in 1,1,2-trichloroethylene T=100°C; 4 h;
参考文献
Martin-Onraet; Gansser; Plat; et al.
Farmaco, Edizione Scientifica, 1985 , vol. 40, # 10 p. 745 - 754
反应条件
1.1: toluene-4-sulfonic acid / ethanol / 1.5 h / Reflux 2.1: trichlorophosphate / 1,2-dichloro-benzene / 1.5 h / 20 °C 2.2: 4 h / 105 °C 2.3: 20 °C View Scheme
参考文献
Vehar, Blaz; Hrast, Martina; Kovac, Andreja; Konc, Janez; Mariner, Katherine; Chopra, Ian; O'Neill, Alex; Janezic, Dusanka; Gobec, Stanislav
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 17 p. 5137 - 5146
反应条件
trichlorophosphate in chlorobenzene 6.5 h; Reflux;
参考文献
Deane, Fiona M.; Miller, Charlotte M.; Maguire, Anita R.; McCarthy, Florence O.
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 4 p. 814 - 823
参考文献
Martin-Onraet; Gansser; Plat; et al.
Farmaco, Edizione Scientifica, 1985 , vol. 40, # 10 p. 745 - 754
反应条件
1.1: 3 h / 115 °C / Inert atmosphere 1.2: 1 h / 20 °C / Molecular sieve; Inert atmosphere 2.1: sodium carbonate; p-toluenesulfonyl chloride / tetrahydrofuran; water / 2 h / 20 °C 2.2: 12 h 2.3: 0 °C / pH 10 3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C 3.2: 0 - 20 °C View Scheme
参考文献
Vehar, Blaz; Hrast, Martina; Kovac, Andreja; Konc, Janez; Mariner, Katherine; Chopra, Ian; O'Neill, Alex; Janezic, Dusanka; Gobec, Stanislav
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 17 p. 5137 - 5146
反应条件
1: 93 percent / KMnO4 / acetone / 3 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 31, # 2 p. 241 - 246
反应条件
1: 93 percent / KMnO4 / acetone / 3 h / Ambient temperature 3: 15 percent / 33percent HBr / acetic acid / 48 h / Heating View Scheme
参考文献
Lancelot, Jean-Charles; Letois, Bertrand; Rault, Sylvain; Robba, Max
Heterocycles, 1990 , vol. 31, # 2 p. 241 - 246
反应条件
1.1: 3 h / 115 °C / Inert atmosphere
1.2: 1 h / 20 °C / Molecular sieve; Inert atmosphere
2.1: sodium carbonate; p-toluenesulfonyl chloride / tetrahydrofuran; water / 2 h / 20 °C
2.2: 12 h
2.3: 0 °C / pH 10
View Scheme
参考文献
Vehar, Blaz; Hrast, Martina; Kovac, Andreja; Konc, Janez; Mariner, Katherine; Chopra, Ian; O'Neill, Alex; Janezic, Dusanka; Gobec, Stanislav
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 17 p. 5137 - 5146
