2,2,2-三氟-1-(1-甲基-1H-吡咯-2-基)乙酮合成路线 (共 4 条)
反应条件
in diethyl ether T=0°C; 4 h;
参考文献
Allen, Annette D.; Kwong-Chip, Jean-Marc; Lin, Wing Cheung; Nguyen, Paul; Tidwell, Thomas T.
Canadian Journal of Chemistry, 1990 , vol. 68, # 10 p. 1709 - 1713
参考文献
Science Union et Cie
Patent: US4267345 A1, 1981 ;
反应条件
sodium hydride in N,N-dimethyl-formamide T=60°C;
参考文献
Kopecky, David J.; Jiao, Xian Yun; Fisher, Ben; McKendry, Sharon; Labelle, Marc; Piper, Derek E.; Coward, Peter; Shiau, Andrew K.; Escaron, Patrick; Danao, Jean; Chai, Anne; Jaen, Juan; Kayser, Frank
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2407 - 2410
反应条件
1: 88 percent / HCl gas / CH2Cl2 / 0.75 h / ice-bath 2: 1.9 g / H2 / 10percent Pd-C / ethyl acetate / 2068.6 Torr View Scheme
参考文献
Barker; Bahia
Tetrahedron, 1990 , vol. 46, # 8 p. 2691 - 2694