3-溴咪唑并[1,2-b]哒嗪合成路线 (共 2 条)
反应条件
3-bromo-6-chloroimidazolt;1,2-bgt;pyridazine hydrobromide-bromine 0.5 h; Ambient temperature;
参考文献
Stanovnik, Branko; Tisler, Miha; Drnovsek, Iztok
Synthesis, 1981 , # 12 p. 987 - 989
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=100°C; 18 h; Inert atmosphereSealed tube; 2: With hydrogenchloride in 1,4-dioxane; methanol
参考文献
MERCK SHARP andamp;; DOHME CORP.; ALTMAN, Michael, D.; BILODEAU, Mark, T.; LIM, Jongwon; NORTHRUP, Alan; STANTON, Matthew, G.; TAOKA, Brandon, M.
Patent: WO2010/83145 A1, 2010 ;
Location in patent: Page/Page column 56-57 ;
WO 2010/083145 A1