(2E)-4-({[(2-甲基-2-丙基)氧基]羰基}氨基)-2-丁烯酸合成路线 （共 3 条）
反应条件
1: diethyl carboxymethylphosphonate With n-butyllithium in tetrahydrofuran T=-60°C; 0.5 h; 2: N-tert-butoxycarbonylglycinal in tetrahydrofuran T=-60 - 25°C; Horner olefination; 4 h;
参考文献
Grison, Claude; Geneve, Stephane; Halbin, Etienne; Coutrot, Philippe
Tetrahedron, 2001 , vol. 57, # 23 p. 4903 - 4923
反应条件
lithium hydroxide hydrate; water in tetrahydrofuran 3 h;
参考文献
McGouran, Joanna F.; Kramer, Holger B.; MacKeen, Mukram M.; Di Gleria, Katalin; Altun, Mikael; Kessler, Benedikt M.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 17 p. 3379 - 3383
反应条件
1.1: 85 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 0.33 h 2.1: n-BuLi / tetrahydrofuran / 0.5 h / -60 °C 2.2: 77 percent / tetrahydrofuran / 4 h / -60 - 25 °C View Scheme
参考文献
Grison, Claude; Geneve, Stephane; Halbin, Etienne; Coutrot, Philippe
Tetrahedron, 2001 , vol. 57, # 23 p. 4903 - 4923
