1: 98 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 2: 93 percent / LiOH 3: 62 percent / DIAD, PPh3, TsOH*H2O / tetrahydrofuran / 2 h / 0 °C 4: 84 percent / I2 / methanol; H2O View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103618', constants.ctx, '0')">1,4-diaza-bicyclo[2.2.2]octane</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605268', constants.ctx, '0')">diethylamine</a> <br /> <br /> &nbsp;

<b>Multi-step reaction with 7 steps<br /> </b>1: 95 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA<br />2: Et₂NH<br />3: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA<br />4: Et₂NH<br />5: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA<br />6: 97 percent<br />7: 96 percent / DABCO, Et₂NH<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1: Et₂NH<br />2: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA<br />3: Et₂NH<br />4: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA<br />5: 97 percent<br />6: 96 percent / DABCO, Et₂NH<br /> <br /> &nbsp;