1: 74 percent / (COCl)2, DMSO, Et3N 2: 99 percent / Ti(IV) complex with (S)-(-)-binaphthyl amino alcohol 3: 100 percent / LiOH / methanol; H2O View Scheme

1: 74 percent / (COCl)2, DMSO, Et3N 2: 95 percent / Ti(IV) complex with (R)-(-)-binaphthyl amino alcohol 3: 100 percent / LiOH / methanol; H2O 4: 98 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, DIEA 5: 93 percent / LiOH 6: 62 percent / DIAD, PPh3, TsOH*H2O / tetrahydrofuran / 2 h / 0 °C 7: 84 percent / I2 / methanol; H2O View Scheme