三甲基硅烷化重氮甲烷合成路线

参考文献

PFIZER PRODUCTS INC.
Patent: WO2008/26046 A1, 2008 ;
Location in patent: Page/Page column 32 ;
WO 2008/026046 A1

215433-30-0

90322-37-52-吲哚酮-4-羧酸

参考文献

Sugen, Inc.
Patent: US6114371 A1, 2000 ;
US 6114371 A

4294-95-52-氨基-4-甲氧基苯甲酸+

18107-18-1三甲基硅烷化重氮甲烷

50413-30-42-氨基-4-甲氧基苯甲酸甲酯

参考文献

EXELIXIS, INC.; ANAND, Neel, Kumar; BLAZEY, Charles, M.; BOWLES, Owen, Joseph; BUHR, Chris, Allen; BUSSENIUS, Joerg; CURTIS, Jeffry, Kimo; DEFINA, Steven, Charles; DUBENKO, Larisa; HARRIS, Jason, R.; JACKSON-UGUETO, Eileen; JOSHI, Anagha; KIM, Angie, Inyoung; TSUHAKI, Amy, Lew; MA, Sunghoon; MANALO, Jean-claire, Limun; NG, Stephanie; PETO, Csaba, J.; RICE Kenneth D.; TSANG, Tsze, H.; ZAHARIA, Cristiana, A.
Patent: WO2010/135524 A1, 2010 ;
Location in patent: Page/Page column 219 ;
WO 2010/135524 A1

480-66-02,4,6-三羟基苯乙酮一水合物+

18107-18-1三甲基硅烷化重氮甲烷

90-24-42-羟基-4,6-二甲氧基苯乙酮+

7507-89-31-(2,6-二羟基-4-甲氧基苯基)乙酮+

3602-54-82',4'-二羟基-6'-甲氧基苯乙酮

参考文献

European Journal of Medicinal Chemistry, , vol. 45, # 9 p. 4258 - 4269

18107-18-1三甲基硅烷化重氮甲烷+

380380-60-95-溴-2-(1H-四唑-5-基)吡啶

380380-64-32-甲基-5-(5-溴吡啶-2-基)四氮唑+

380380-63-25-溴-2-(1-甲基-1H-四唑-5-基)-吡啶

参考文献

Clark, Richard F.; Djuric, Stevan; Ma, Zhenkun; Phan, Ly; Rupp, Michael
Patent: US2004/33970 A1, 2004 ;
Location in patent: Page/Page column 9 ;

14441-90-85-苯基-3-异恶唑羧酸+

18107-18-1三甲基硅烷化重氮甲烷

51677-09-95-苯基异噁唑-3-甲酸甲酯

参考文献

BRISTOL-MYERS SQUIBB COMPANY; WATTERSON, Scott, Hunter; DYCKMAN, Alaric, J.; PITTS, William, J.; SPERGEL, Steven, H.
Patent: WO2010/85581 A1, 2010 ;
Location in patent: Page/Page column 82 ;
WO 2010/085581 A1

23761-23-13-氧代环丁烷基羧酸+

18107-18-1三甲基硅烷化重氮甲烷

4934-99-03-羟基环丁烷羧酸甲酯

参考文献

SCHERING CORPORATION
Patent: WO2008/130581 A1, 2008 ;
Location in patent: Page/Page column 201-202 ;
WO 2008/130581 A1

17159-79-4对环己酮甲酸乙酯+

18107-18-1三甲基硅烷化重氮甲烷

122898-08-2+

171361-65-21-噁螺[2.5]辛烷-6-羧酸乙酯+

171361-62-9

参考文献

Alonso, Francisco; Mico, Irene; Najera, Carmen; Sansano, Jose M.; Yus, Miguel; et al.
Tetrahedron, 1995 , vol. 51, # 37 p. 10259 - 10280

505-48-6辛二酸+

18107-18-1三甲基硅烷化重氮甲烷

1732-09-8辛二酸二甲酯

参考文献

Schmidt, Andrea-Katharina C.; Stark, Christian B. W.
Organic Letters, 2011 , vol. 13, # 21 p. 5788 - 5791

119-67-5邻羧基苯甲醛+

18107-18-1三甲基硅烷化重氮甲烷

4122-56-92-醛基苯甲酸甲酯

参考文献

Gunawan, Steven; Hulme, Christopher
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 36 p. 6036 - 6046