反应条件
1: N-benzyloxycarbonyl-(S)-proline With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; Inert atmosphere; 2: diazomethyl-trimethyl-silane in diethyl ether; dichloromethane T=0 - 20°C; 4 h; Inert atmosphere; 3: With hydrogen bromide in diethyl ether; dichloromethane T=0 - 20°C; 16 h;
参考文献
ZALICUS PHARMACEUTICALS LTD.; PAJOUHESH, Hassan, A.; HOLLAND, Richard; ZHANG, Lingyun; PAJOUHESH, Hossein, O.; LAMONTAGNE, Jason; WHELAN, Brendan; SHORT, Glenn, F., III.; ROMERO, Donna, L.
Patent: WO2013/131018 A1, 2013 ;
Location in patent: Page/Page column 43; 44 ;