三甲基硅烷化重氮甲烷合成路线

参考文献

Sweeney, Zachary K.; Harris, Seth F.; Arora, Nidhi; Javanbakht, Hassan; Li, Yu; Fretland, Jennifer; Davidson, James P.; Billedeau, J. Roland; Gleason, Shelley K.; Hirschfeld, Donald; Kennedy-Smith, Joshua J.; Mirzadegan, Taraneh; Roetz, Ralf; Smith, Mark; Sperry, Sarah; Suh, Judy M.; Wu, Jeffrey; Tsing, Stan; Villasenor, Armando G.; Paul, Amber; Su, Guoping; Heilek, Gabrielle; Hang, Julie Q.; Zhou, Amy S.; Jernelius, Jesper A.; Zang, Fang-Jie; Klumpp, Klaus
Journal of Medicinal Chemistry, 2008 , vol. 51, # 23 p. 7449 - 7458

4589-66-6(1,2-二甲基-1H-苯并咪唑-5-基)甲醇+

18107-18-1三甲基硅烷化重氮甲烷

256936-11-51,2-二甲基-1H-苯并[d]咪唑-5-羧酸甲酯

参考文献

NOVARTIS AG
Patent: US2012/35168 A1, 2012 ;
Location in patent: Page/Page column 82 ;
US 20120035168 A1

3641-51-8(R)-(+)-甲基丁二酸+

18107-18-1三甲基硅烷化重氮甲烷

22644-27-5R-2-甲基琥珀酸甲酯

参考文献

Zupancic, Borut; Mohar, Barbara; Stephan, Michel
Organic Letters, 2010 , vol. 12, # 6 p. 1296 - 1299

29241-62-15-溴-6-氯烟酸+

18107-18-1三甲基硅烷化重氮甲烷

78686-77-85-溴-6-氯烟酸甲酯

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BENENATO, Kerry, Ellen; CHOY, Allison, Laura; HALE, Michael, Robin; HILL, Pamela; MARONE, Valerie; MILLER, Matthew
Patent: WO2010/100475 A1, 2010 ;
Location in patent: Page/Page column 74-75 ;
WO 2010/100475 A1

212650-43-64-Boc-3-吗啉甲酸+

18107-18-1三甲基硅烷化重氮甲烷

212650-45-8吗啉-3,4-二羧酸- -4-叔丁酯-3-甲酯

参考文献

EVOTEC NEUROSCIENCES GMBH
Patent: WO2008/125570 A1, 2008 ;
Location in patent: Page/Page column 47 ;
WO 2008/125570 A1

156270-06-31H-吡咯并[2,3-b]吡啶-3-甲酸+

18107-18-1三甲基硅烷化重氮甲烷

808137-94-21H-吡咯并[2,3-B]吡啶-3-羧酸甲酯

参考文献

SUNESIS PHARMACEUTICALS; BIOGEN IDEC, INC.
Patent: WO2008/5457 A2, 2008 ;
Location in patent: Page/Page column 78 ;
WO 2008/005457 A2

7206-70-4+

18107-18-1三甲基硅烷化重氮甲烷

20896-27-9

参考文献

Theravance, Inc.
Patent: US2006/35931 A1, 2006 ;
Location in patent: Page/Page column 12 ;

20896-27-9

参考文献

THERAVANCE, INC.
Patent: WO2004/89892 A2, 2004 ;
Location in patent: Page 118 ;
WO 2004/089892 A2

58584-92-2+

18107-18-1三甲基硅烷化重氮甲烷

849805-25-0

参考文献

Vallerini, Gian Paolo; Amori, Laura; Beato, Claudia; Tararina, Margarita; Wang, Xiao-Dan; Schwarcz, Robert; Costantino, Gabriele
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9482 - 9495

602-00-6+

18107-18-1三甲基硅烷化重氮甲烷

89942-77-8

参考文献

Tipparaju, Suresh K.; Joyasawal, Sipak; Pieroni, Marco; Kaiser, Marcel; Brun, Reto; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 23 p. 7344 - 7347